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Quantifying endosomal escape in vivo to guide lipid nanoparticle design

delete2026-03-11
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PRE
AI
Z
Zhengwei Liu
Y
Yizhou Dong *
DOI：10.1038/s41587-026-03047-xdelete
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Abstract

Abstract

En 中文
A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.
Keywords:
Gene therapy
Nanoparticles
Life Sciences
general
Biotechnology
Biomedicine
Agriculture
Biomedical Engineering/Biotechnology
Bioinformatics

Journal

Nature Biotechnology cover
Nature Biotechnology
IF:
41.7
Papers:
1.2W
Citations:
10.1W

Organization

I
Icahn School of Medicine at Mount Sinai
Scholars:
4.6W
Papers: 3.4W
Citations: 56
Cited Papers

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