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Quantitative single-base m6A profiling reveals dynamic reprogramming, evolutionary conservation and transcriptional regulation in bacteria
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DOI：10.1016/j.celrep.2026.117831.png)
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Abstract
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• Comprehensive single-base m6A maps reveal bacteria-specific distribution patterns • Bacterial m6A sites exhibit local clustering with elevated methylation levels • m6A is dynamically regulated across growth phases and culture conditions • m6A is associated with reduced bacterial mRNA abundance and increased RNA stability
Keywords:
N6-methyladenosine
m6A
RNA methylation
single-base resolution
bacteria
epigenetic
bacterial epitranscriptomics
CP: Microbiology
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