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Quassinoids from Eurycoma longifolia
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DOI：10.1021/np900486f.png)
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Ten new structurally diverse quassinoids (1-10) and 14 known Compounds were isolated from the steins of Eurycoma longifolia. The new compounds were two eurycomanone-type C-20 quassinoids (1, 2), one klaineanone-type C-20 quassinoid (3), one C-19 quassinoid (4) with a 1,2-seco-1-nor-6(5 -> 10)-abeo-picrasan-2,5-olide skeleton, and six eurycomalactone-type C-19 quassinoids (5-10). Compounds 5 and 6 both possessed a 3,4-epoxy group observed for the first time in eurycomalactones. Compound I had an alpha-oriented OH group at C-14 that had not been reported previously in eurycomanone-type quassinoids. All of the isolates were evaluated for cytotoxicity toward the highly metastatic HT-1080 human fibrosarcoma cell line, and compounds 11, 23, and 24 showed potent cytotoxicity (IC50 values 0.93-1.1 mu M).
Keyword:
ANTIMALARIAL CONSTITUENTS
CYTOTOXIC QUASSINOIDS
MEDICINAL-PLANTS
ROOTS
JACK
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3.6
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1.2W
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2.9W
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