.png){kind=icon}
返回
Randomized Intervention Trial to Decrease Bisphenol A Urine Concentrations in Women: Pilot Study
.png){kind=icon}
OA
AI
DOI：10.1089/jwh.2016.5746.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Background: Previous studies have shown that women have higher concentrations of the endocrine disruptor bisphenol A (BPA), but an intervention to reduce BPA is lacking in women. To test the hypothesis that an intervention to reduce BPA would decrease urinary BPA concentrations over 3 weeks, 24 women (mean +/- standard deviation [SD]; 22.1 +/- 2.8 kg/m(2) body mass index, 20.9 +/- 1.5 years) were randomly assigned to an intervention or control. Materials and Methods: The intervention included weekly face-to-face meetings to reduce BPA exposures from food, cosmetics, and other packaged products. Women were provided with BPA-free cosmetics, hygiene, glass food/water containers, and daily self-monitored major sources of BPA. Fasting urine BPA and creatinine concentrations, and weight were assessed at study entry and after 3 weeks. Results: A significant (p = 0.04) treatment x time interaction effect was observed on creatinine-adjusted BPA concentrations. From study entry to 3 weeks, women in the intervention significantly decreased geometric mean creatinine-adjusted urinary BPA by -0.71 ng/m, whereas women in the control significantly increased urinary BPA by 0.32 ng/mL (p = 0.04). Additionally, from study entry to 3 weeks, women in the intervention significantly lost weight -0.28 +/- 0.44 kg, whereas women in the control significantly gained weight +1.65 +/- 0.74 kg (p = 0.03). Changes in creatinine-adjusted BPA concentrations and weight were not significantly related (p = 0.67). Conclusion: In this pilot study, a 3-week intervention decreased urinary BPA concentrations in women. Future clinical trials are needed to confirm these results and to examine whether a similar BPA intervention positively impacts risk markers in the pathogenesis of cardiovascular disease and diabetes.
Keyword:
BPA
intervention
weight
endocrine disruptors
diet
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
J
IF:
1.9
论文数:
4.5K
被引数:
9.4K
机构
引用论文
Food Packaging and Bisphenol A and Bis(2-Ethyhexyl) Phthalate Exposure: Findings from a Dietary Intervention食品包装与双酚a和邻苯二甲酸双 (2-乙基己基) 酯暴露: 饮食干预的结果OAAI
OAAI分享收藏Successful behavior change in obesity interventions in adults: a systematic review of self-regulation mediators.png)
BMC MEDICINEOAAI
BMC MEDICINEIF8.3
OAAI分享收藏
查看更多内容