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Real-time multi-channel SPR sensing based on DMD-enabled angular interrogation
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DOI：10.1364/OE.26.024627.png)
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This paper reports a digital micro-mirror device (DMD)-enabled real-time multi-channel biosensing system based on angular interrogation surface plasmon resonance (SPR). In the experiments, angular scanning is achieved by a DMD that facilitates SPR measurements using a single-point photodetector. In the four-channel measurement setup, real-time monitoring of bovine serum albumin (BSA) and anti-BSA binding interactions is performed at various concentration levels. The experimental results have verified that the system has a resolution of 3.54 x 10(-6) RIU (refractive index unit); and a detection limit of 9 ng/mL. The new DMD-based SPR interrogation system presents a new design route for practical solid-state SPR biosensing with a user-selectable range of interrogation, enhanced signal-to-noise ratio, and fast data throughput. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Keyword:
SURFACE-PLASMON RESONANCE
OPTICAL-CONSTANTS
BIOSENSORS
PHASE
SENSORS
LIGHT
TECHNOLOGY
CHALLENGES
TOOLS
期刊
IF:
3.3
论文数:
6.1W
被引数:
14.3W
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