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Real-Time Passive Acoustic Mapping Using Sparse Matrix Multiplication
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DOI：10.1109/TUFFC.2020.3001848.png)
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摘要
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Passive acoustic mapping enables the spatiotemporal monitoring of cavitation with circulating microbubbles during focused ultrasound (FUS)-mediated blood-brain barrier opening. However, the computational load for processing large data sets of cavitation maps or more complex algorithms limit the visualization in real-time for treatment monitoring and adjustment. In this study, we implemented a graphical processing unit (GPU)- accelerated sparse matrix-based beamforming and time exposure acoustics in a neuronavigation-guided ultrasound system for real-time spatiotemporal monitoring of cavitation. The system performance was tested in silico through benchmarking, in vitro using nonhuman primate (NHP) and human skull specimens, and demonstrated in vivo in NHPs. We demonstrated the stability of the cavitation map for integration times longer than 62.5 mu s. A compromise between real-time displaying and cavitation map quality obtained from beamformed RF data sets with a size of 2000x128x30 (axial pixelsxlateral pixelsxsamples) was achieved for an integration time of 1.44 mu s, which required a computational time of 0.27 s (frame rate of 3.7 Hz) and could be displayed in real-time between pulses at PRF = 2 Hz. Our benchmarking tests show that the GPU sparse- matrix algorithm processed the RF data set at a computational rate of 0.03 +/- 0.01 mu s/pixel/sample, which enables adjusting the frame rate and the integration time as needed. The neuronavigation system with real-time implementation of cavitation mapping facilitated the localization of the cavitation activity and helped to identify distortions due to FUS phase aberration. The in vivo test of themethod demonstrated the feasibility of GPU-accelerated sparse matrix computing in a close to a clinical condition, where focus distortions exemplify problems during treatment. These experimental conditions show the need for spatiotemporal monitoring of cavitation with real-time capability that enables the operator to correct or halt the sonication in case substantial aberrations are observed.
Keyword:
Drug delivery
graphical processing unit (GPU)-acceleration
nonhuman primate (NHP)
passive acoustic mapping (PAM)
sparse matrix
ultrasound-mediated blood-brain barrier (BBB) opening
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3.7
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6.7K
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