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Real-world assessment of prophylactic anakinra on neurotoxicity and cytokine release syndrome after CD19 CAR T-cell therapy in R/R B-cell lymphoma: An inverse probability of treatment weighting analysis

delete2026-06-17
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PRE
AI
N
Neela Easton
M
Mia Andreoli
H
Herman van Besien
C
Caitlin Gribbin
M
Michelle Pasciolla
A
Anna Alperovich
M
Mateo Mejia Saldarriaga
B
Barbara Ma
N
Nora Chokr
A
Amer Assal
J
Joshua Fein
S
Sebastian Mayer
A
Alexandra Gomez-Arteaga
D
Daniel Choi
T
Tsiporah Shore
C
Christopher S. Hackett
J
Juliet Barker
S
Samuel Yamshon *
DOI:10.1016/j.jtct.2026.06.008delete
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Abstract

Abstract

En 中文
• Prophylactic anakinra did not reduce grade ≥3 CAR T-associated neurotoxicity syndrome. • Prophylactic anakinra was associated with increased grade ≥3 infections. • No survival or response rate differences observed with anakinra prophylaxis. • Caution warranted for routine anakinra use.

Journal

Transplantation and Cellular Therapy cover
Transplantation and Cellular Therapy
IF:
4.4
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2.1K
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hematology & medical oncology
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nyu langone
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M
Medicine
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