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Recent Developments on Five-Component Reactions
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DOI：10.3390/molecules26071986.png)
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摘要
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Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.
Keyword:
multicomponent reaction
five-component
pseudo
one-pot
cascade
consecutive
green synthesis
heterocycle
pot
atom
step economy
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4.6
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6.5W
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23.7W
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