RECONCILING DESIGN-BASED AND MODEL-BASED CAUSAL INFERENCES FOR SPLIT-PLOT EXPERIMENTS

Anqi Zhao

doi:10.1214/21-AOS2144

RECONCILING DESIGN-BASED AND MODEL-BASED CAUSAL INFERENCES FOR SPLIT-PLOT EXPERIMENTS

2022-04-01

7

OA

AI

DOI：10.1214/21-AOS2144

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The split-plot design arose from agricultural science with experimental units, also known as the subplots, nested within groups known as the whole plots. It assigns different interventions at the whole-plot and subplot levels, respectively, providing a convenient way to accommodate hard-to-change factors. By design, subplots within the same whole plot receive the same level of the whole-plot intervention, and thereby induce a group structure on the final treatment assignments. A common strategy is to run an ordinary least squares (oLs) regression of the outcome on the treatment indicators coupled with the robust standard errors clustered at the whole-plot level. It does not give consistent estimators for the treatment effects of interest when the whole-plot sizes vary. Another common strategy is to fit a linear mixed-effects model of the outcome with normal random effects and errors. It is a purely model-based approach and can be sensitive to violations of the parametric assumptions. In contrast, design-based inference assumes no outcome models and relies solely on the controllable randomization mechanism determined by the physical experiment. We first extend the existing design-based inference based on the Horvitz-Thompson estimator to the Hajek estimator, and establish the finite-population central limit theorem for both under split-plot randomization. We then reconcile the results with those under the model-based approach, and propose two regression strategies, namely (i) the weighted least squares (wLs) fit of the unit-level data based on the inverse probability weighting and (ii) the OLS fit of the aggregate data based on whole-plot total outcomes, to reproduce the Hajek and Horvitz- Thompson estimators, respectively. This, together with the asymptotic conservativeness of the corresponding cluster-robust covariances for estimating the true design-based covariances as we establish in the process, justifies the validity of the regression estimators for design-based inference. In light of the flexibility of regression formulation for covariate adjustment, we further extend the theory to the case with covariates, and demonstrate the efficiency gain by regression-based covariate adjustment via both asymptotic theory and simulation. Importantly, all our theories are either numeric or design-based, and hold regardless of how well the regression equations represent the true data generating process.

Keyword:

Cluster randomization

cluster-robust standard error

covariate adjustment

inverse probability weighting

potential outcome

randomization inference

RECONCILING DESIGN-BASED AND MODEL-BASED CAUSAL INFERENCES FOR SPLIT-PLOT EXPERIMENTS

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