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Recursive partitioning for tumor classification with gene expression microarray data

delete2001-05-29
delete191
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OA
AI
H
Heping Zhang *
C
Chang‐Yung Yu
B
Burton H. Singer
M
Momiao Xiong
DOI:10.1073/pnas.111153698delete
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摘要

摘要

En 中文
Precise classification of tumors is critically important for cancer diagnosis and treatment. It is also a scientifically challenging task. Recently, efforts have been made to use gene expression profiles to improve the precision of classification, with limited success. Using a published data set for purposes of comparison, we introduce a methodology based on classification trees and demonstrate that it is significantly more accurate for discriminating among distinct colon cancer tissues than other statistical approaches used heretofore. In addition, competing classification trees are displayed, which suggest that different genes may coregulate colon cancers.
Keyword:
OLIGONUCLEOTIDE ARRAYS
CLUSTERING ANALYSIS
PATTERNS
CANCER
CELLS
DIFFERENTIATION
IDENTIFICATION
HYBRIDIZATION
GENOME
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P
Proceedings of the National Academy of Sciences of the United States of America
IF:
9.1
论文数:
10.8W
被引数:
73.5W

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