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Reevaluating thalamic contributions to pain: A translational framework for precision neuromodulation

delete2026-02-07
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PRE
AI
Z
Zhenjiang Li
F
Fengrui Zhang
J
Jie Ren
X
Xuejing Lu *
L
Li Hu *
DOI：10.1016/j.plrev.2026.02.001delete
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Abstract

Abstract

En 中文
• Ventral and posterior thalamus mediate both sensory discrimination and hypersensitivity in pain. • Medial and intralaminar nuclei integrate sensory-affective signals and facilitate pain-related emotional comorbidities. • Emerging electromagnetic and acoustic tools advance thalamic-targeted neuromodulation for analgesia. • A precision neuromodulation framework is highly needed to advance chronic pain management.
Keywords:
Thalamus
Chronic pain
Cross-species
Neuromodulation
Precision neuromodulation framework

Journal

Physics of Life Reviews cover
Physics of Life Reviews
IF:
14.3
Papers:
1.9K
Citations:
2.5K

Organization

C
chengdu medical college
Scholars:
778
Papers: 225
Citations: 0
C
Chinese Academy of Sciences
Scholars:
3.9W
Papers: 1.5W
Citations: 58.4W
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