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Regional alterations of parvalbumin interneurons in human App knock-in mouse model of Alzheimer’s disease pathology
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DOI：10.1016/j.neurobiolaging.2026.05.005.png)
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Abstract
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• Regional differences are found at early time point in hAPP-KI mouse model of AD. • PV interneurons in the entorhinal cortex are less excitable. • Excitatory neurons in the entorhinal cortex become more active at this time point. • PV and excitatory cells exhibit minor differences in the visual cortex.
Keywords:
Alzheimer’s disease
Electrophysiology
APP
Amyloid precursor protein
Interneurons
Parvalbumin
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