Remote Optogenetics Using Up/Down-Conversion Phosphors

T. Matsubara

doi:10.3389/fmolb.2021.771717

2021-11-05

T. Matsubara

Takayuki Yamashita *

DOI：10.3389/fmolb.2021.771717

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摘要

En 中文

Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum. As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body. Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers. Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors. The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues. Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.

Keyword:

optogenetics

upconversion

scintillator

X-rays

behavior

near-infrared

wireless

rhodopsin

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Frontiers in Molecular Biosciences

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论文数:

6.1K

被引数:

2.3W

机构

fujita health university

学者数:

145

论文数: 49

被引数: 200

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