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Replacement as an aging intervention

delete2025-05-08
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PRE
AI
S
Sierra Lore
J
Jesse R. Poganik
A
Anthony Atala
G
George M. Church
V
Vadim N. Gladyshev
M
Morten Scheibye‐Knudsen
DOI:10.1038/s43587-025-00858-6delete
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摘要

摘要

En 中文
在衰老研究领域取得了显著进展,持续深化我们对衰老基本机制的理解,但尚缺乏明确证明可有效延缓人类衰老过程的干预措施。相比之下,诸如关节置换、起搏器植入和移植疗法等替代性干预措施,在恢复损伤或疾病状态下的功能方面已有悠久历史。本文将替代性生物和合成策略视为衰老干预手段,探讨组织工程领域的创新,例如利用支架或生物打印生成功能性组织、通过基因工程增强供受体相容性的方法,以及细胞疗法和异种移植策略的最新进展。我们研究了包括假体、外部设备和脑机接口在内的合成方法。此外,我们评估了小鼠异时性异种联体实验和供受体年龄不匹配移植的证据,以探讨个性化替代方法是否可能带来系统性益处。最后,我们概述了推进替代疗法作为应对衰老的可行、可扩展且合乎伦理干预措施所需克服的关键挑战和未来方向。
Keyword:
STEM-CELL TRANSPLANTATION
RECENT PROGRESS
EARLY HISTORY
THERAPY
DEVICES
DISEASE
DIFFERENTIATION
REJUVENATION
BIOREACTORS
GENERATION

期刊

Nature Aging 封面图
Nature Aging
IF:
19.4
论文数:
1.2K
被引数:
6.4K

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