Reprogramming-Evolving Path to Functional Surrogate β-Cells

Eric Kalo

doi:10.3390/cells11182813

2022-09-08

Eric Kalo *

Scott Read

Golo Ahlenstiel

DOI：10.3390/cells11182813

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摘要

En 中文

Numerous cell sources are being explored to replenish functional beta-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity permitting differentiation along new lineages into insulin-secreting beta-cells. In this review, we explore emerging reprograming pathways that aim to generate bone fide insulin producing cells. We focus on small molecules and key transcriptional regulators that orchestrate phenotypic conversion and maintenance of engineered cells.

Keyword:

beta-cell

diabetes mellitus

cell sources

reprogramming

insulin

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期刊

Cells

IF:

5.2

论文数:

2.1W

被引数:

10.7W

机构

Western Sydney University

学者数:

474

论文数: 219

被引数: 0

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