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Reshaping the Ventricle From Within
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DOI：10.1016/j.jacbts.2022.07.002.png)
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Abstract
En 中文
MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance. MIRTH may help treat dilated cardiomyopathy. Clinical investigation is warranted. (J Am Coll Cardiol Basic Trans Science 2023;8:37-50) Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords:
cardiac repair
cardiomyopathy
heart failure
etiology
mortality
surgery
surgical ventricular restoration
ventricular remodeling
ventriculoplasty
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