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Resolving sorting mechanisms into exosomes
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DOI：10.1038/cr.2015.39.png)
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摘要
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The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.
Keyword:
EXTRACELLULAR VESICLES
BIOGENESIS
CD63
ALIX
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Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TfR for sorting into exosomes.png)
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