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Respiratory patterns and baroreflex function in heart failure
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DOI：10.1038/s41598-023-29271-y.png)
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摘要
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Little is known on the effects of respiratory patterns on baroreflex function in heart failure (HF). Patients with HF (n=30, age 61.6 +/- 10 years, mean +/- SD) and healthy controls (CNT, n=10, age 58.9 +/- 5.6 years) having their R-R interval (RRI, EKG), systolic arterial blood pressure (SBP, Finapres) and respiratory signal (RSP, Respitrace) monitored, were subjected to three recording sessions: free-breathing, fast- (>= 12 bpm) and slow- (6 bpm) paced breathing. Baroreflex sensitivity (BRS) and power spectra of RRI, SBP, and RSP signals were calculated. During free-breathing, compared to CNT, HF patients showed a significantly greater modulation of respiratory volumes in the very-low-frequency (<0.04 Hz) range and their BRS was not significantly different from that of CNT. During fast-paced breathing, when very-low-frequency modulations of respiration were reduced, BRS of HF patients was significantly lower than that of CNT and lower than during free breathing. During slow-paced breathing, BRS became again significantly higher than during fast breathing. In conclusion: (1) in free-breathing HF patients is present a greater modulation of respiratory volumes in the very-low-frequency range; (2) in HF patients modulation of respiration in the very-low and low frequency (around 0.1 Hz) ranges contributes to preserve baroreflex-mediated control of heart rate.
Keyword:
SYMPATHETIC-NERVE ACTIVITY
BRAIN NATRIURETIC PEPTIDE
PULMONARY GAS-EXCHANGE
BLOOD-PRESSURE
SINUS ARRHYTHMIA
VARIABILITY
BARORECEPTOR
SENSITIVITY
SLOW
MODULATION
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期刊
IF:
3.9
论文数:
28.0W
被引数:
83.5W
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