Rhinitis Phenotypes Based on Multimorbidities

doi:10.1016/j.jaip.2024.04.013

2024-06-01

PRE

Álvaro A. Cruz *

Jean Bousquet

DOI：10.1016/j.jaip.2024.04.013

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Chronic allergic and nonallergic rhinitis are common phenotypes of a highly prevalent disorder of the upper airways, often associated with asthma. 1 Clinical data, epidemiologic studies, and mHealthbased and genomic approaches indicate the existence of 2 distinct diseases: rhinitis alone and rhinitis D asthma, which may be allergic or less often nonallergic. Both disease phenotypes need to be further characterized, because allergic conjunctivitis, food allergy, and atopic dermatitis, often present in patients with allergic rhinitis, may be considered as independent multimorbidities. Thus, the concept multimorbid allergic disease is more appropriate than one-airway-one-disease. In a meta -analysis, atopic dermatitis was strongly associated with allergic and nonallergic rhinitis, but not with rhinitis and asthma. 2 Asthma alone may also be associated with non - type 2 mechanisms. 3 The distinction between rhinitis alone and rhinitis and asthma was found in all the 12 countries studied using an mHealth app (MASK -air) in Europe and Latin America. These data indicate that the distinction between the 2 diseases is independent of allergen exposure. 4 (c) 2024 American Academy of Allergy, Asthma & Immunology

Keyword:

Rhinitis

Asthma

Phenotype

Multimorbidity

Management

Allergy

期刊

Journal of Allergy and Clinical Immunology in Practice

IF:

6.6

论文数:

5.3K

被引数:

1.6W

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chu de montpellier

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被引数: 5

Universidade Federal da Bahia

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9.4K

论文数: 5.3K

被引数: 4.3K

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