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摘要
En 中文
Mammalian messenger RNA (mRNA) and long noncoding RNA (IncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N-6-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/IncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.
Keyword:
TUMOR 1-ASSOCIATING PROTEIN
MESSENGER-RNA
METHYLATED NUCLEOSIDES
CANDIDATE GENES
RIBOSOMAL-RNA
NUCLEAR-RNA
FTO GENE
HUR
N-6-METHYLADENOSINE
ALKB
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Interplay between microRNAs and RNA-binding proteins determines developmental processes.png)
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