RNA origami: design, simulation and application

doi:10.1080/15476286.2023.2237719

2023-07-27

DOI：10.1080/15476286.2023.2237719

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摘要

En 中文

Design strategies for DNA and RNA nanostructures have developed along parallel lines for the past 30 years, from small structural motifs derived from biology to large 'origami' structures with thousands to tens of thousands of bases. With the recent publication of numerous RNA origami structures and improved design methods-even permitting co-transcriptional folding of kilobase-sized structures - the RNA nanotechnolgy field is at an inflection point. Here, we review the key achievements which inspired and enabled RNA origami design and draw comparisons with the development and applications of DNA origami structures. We further present the available computational tools for the design and the simulation, which will be key to the growth of the RNA origami community. Finally, we portray the transition from RNA origami structure to function. Several functional RNA origami structures exist already, their expression in cells has been demonstrated and first applications in cell biology have already been realized. Overall, we foresee that the fast-paced RNA origami field will provide new molecular hardware for biophysics, synthetic biology and biomedicine, complementing the DNA origami toolbox.

Keyword:

RNA origami

RNA nanotechnology

DNA origami

co-transcriptional folding

RNA nanostructures

genetic encoding

computational design

molecular simulation

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期刊

RNA Biology

IF:

3.4

论文数:

2.6K

被引数:

7.8K

机构

Ruprecht Karls University Heidelberg

学者数:

5.6W

论文数: 4.3W

被引数: 66

Max Planck Society

学者数:

8.2W

论文数: 7.7W

被引数: 3.3W

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