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Rolling-circle transposons in eukaryotes
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DOI：10.1073/pnas.151269298.png)
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摘要
En 中文
All eukaryotic DNA transposons reported so far belong to a single category of elements transposed by the so-called cut-and-paste mechanism. Here, we report a previously unknown category of eukaryotic DNA transposons, Helitron, which transpose by rolling-circle replication. Autonomous Helitrons encode a 5 ' -to-3 ' DNA helicase and nuclease/ligase similar to those encoded by known rolling-circle replicons. Helitron-like transposons have conservative 5 ' -TC and CTRR-3 ' termini and do not have terminal inverted repeats, They contain 16- to 20-bp hairpins separated by 10-12 nucleotides from the 3 ' -end and transpose precisely between the 5 ' -A and T-3 ', with no modifications of the AT target sites. Together with their multiple diverged nonautonomous descendants, Helitrons constitute approximate to2% of both the Arabidopsis thaliana and Caenorhabditis elegans genomes and also colonize the Oriza sativa genome. Sequence conservation suggests that Helitrons continue to be transposed.
Keyword:
REPLICATION PROTEIN-A
DNA HELICASE
ELEMENTS
ALIGNMENT
DATABASE
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被引数:
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