arrow
返回

Rubisco Function, Evolution, and Engineering

delete2023-06-20
delete31
delete
OA
AI
N
Noam Prywes
N
Naiya R. Phillips
O
Owen T. Tuck
L
Luis E. Valentin-Alvarado
D
David F. Savage *
DOI:10.1146/annurev-biochem-040320-101244delete
delete原文链接
delete原文求助
delete分享
delete收藏
摘要

摘要

En 中文
Carbon fixation is the process by which CO2 is converted from a gas into biomass. The Calvin-Benson-Bassham cycle (CBB) is the dominant carbon-consuming pathway on Earth, driving >99.5% of the similar to 120 billion tons of carbon that are converted to sugar by plants, algae, and cyanobacteria. The carboxylase enzyme in the CBB, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco), fixes one CO2 molecule per turn of the cycle into bioavailable sugars. Despite being critical to the assimilation of carbon, rubisco's kinetic rate is not very fast, limiting flux through the pathway. This bottleneck presents a paradox: Why has rubisco not evolved to be a better catalyst? Many hypothesize that the catalytic mechanism of rubisco is subject to one or more trade-offs and that rubisco variants have been optimized for their native physiological environment. Here, we review the evolution and biochemistry of rubisco through the lens of structure and mechanism in order to understand what trade-offs limit its improvement. We also review the many attempts to improve rubisco itself and thereby promote plant growth.
Keyword:
rubisco
carbon fixation
enzyme engineering
Calvin cycle
carboxylases

期刊

Annual Review of Biochemistry 封面图
Annual Review of Biochemistry
IF:
20.5
论文数:
2.2K
被引数:
2.1W

机构

U
University of California Berkeley
学者数:
3.5W
论文数: 2.8W
被引数: 11.3W
University of California System 封面图
University of California System
学者数:
37.7W
论文数: 33.8W
被引数: 6.6K
引用论文

引用论文

Detection of high-impedance fault in low-voltage DC distribution system via mathematical morphology
err2016-09-28
err0
errOAAI
errYun-Sik Oh; Joon Han; Gi-Hyeon Gwon; Doo-Ung Kim; Chul-Ho Noh; Chul-Hwan Kim; Toshihisa Funabashi; Tomonobu Senjyu
err分享
err收藏
Regulation of poly(ADP-ribose) polymerase mRNA levels during compensatory and mitogen-induced growth of rat liver
err1990-06-01
err0
PREAI
errMarta Menegazzi; Alessandra Carcereri De Prati; Giovanna Maria Ledda-Columbano; Amedeo Columbano; Kazuhiko Uchida; Masanao Miwa; Hisanori Suzuki
err分享
err收藏
err分享
err收藏
Cosmological inflation cries out for supersymmetry
err1982-12-01
err0
errOAAI
errJohn Ellis; D.V. Nanopoulos; Keith A. Olive; K. Tamvakis
err分享
err收藏
Evolutionary trends in RuBisCO kinetics and their co-evolution with CO2 concentrating mechanismsRuBisCO动力学的演化趋势及其与CO2浓缩机制的共同演化
err2020-01-02
err104
errOAAI
errIniguez, Concepcion; Capo-Bauca, Sebastia; Niinemets, Ulo; Stoll, Heather; Aguilo-Nicolau, Pere; Galmes, Jeroni
err分享
err收藏
Rubisco is not really so bad
err2018-02-28
err75
errOAAI
errBathellier, Camille; Tcherkez, Guillaume; Lorimer, George H.; Farquhar, Graham D.
err分享
err收藏
学者 查看更多内容