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SARM1-Dependent Antimetabolic Cancer Therapy

delete2026-07-25
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OA
AI
A
Alice Molli
D
Daniela Buonvicino
A
Andrea Lapucci
L
Luisa Maresca
J
Jose Maria Lanza-Arnaiz
S
Simone Polvani
F
Francesca Cialdai
G
Giacomo Insero
T
Tommaso Mello
B
Barbara Stecca
L
Laura Formentini
A
Alberto Chiarugi *
DOI:10.1016/j.canlet.2026.218762delete
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Abstract

Abstract

En 中文
• Transduction of active SARM1 NADase prompts bioenergetic failure in cancer cells. • Tumor xenografts undergo rapid regression when prompted to express active SARM1. • Data disclose the anticancer potential of SARM1 gene therapy.
Keywords:
SARM1
NAD metabolism
cancer
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cancer Letters cover
Cancer Letters
IF:
10.1
Papers:
1.7W
Citations:
4.3W

Organization

U
university of florence
Scholars:
4.1W
Papers: 3.1W
Citations: 42
I
institute for cancer research and prevention
Scholars:
3
Papers: 1
Citations: 0
U
universidad autonóma de madrid
Scholars:
191
Papers: 88
Citations: 0
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