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SecA: a potential antimicrobial target
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DOI：10.4155/FMC.15.42.png)
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摘要
En 中文
There is a consensus in the medical profession of the pressing need for novel antimicrobial agents due to issues related to drug resistance. In practice, solutions to this problem to a large degree lie with the identification of new and vital targets in bacteria and subsequently designing their inhibitors. We consider SecA a very promising antimicrobial target. In this review, we compile and analyze information available on SecA to show that inhibition of SecA has a multitude of consequences. Furthermore, we discuss issues critical to the design and evaluation of SecA inhibitors.
Keyword:
ESCHERICHIA-COLI SECA
PROTEIN-CONDUCTING CHANNELS
TRANSLOCATION ATPASE SECA
BACILLUS-SUBTILIS SECA
IN-VITRO
MYCOBACTERIUM-TUBERCULOSIS
PREPROTEIN TRANSLOCASE
DIMERIC SECA
STREPTOCOCCUS-GORDONII
MEMBRANE INSERTION
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IF:
3.4
论文数:
3.0K
被引数:
6.2K
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