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Second harmonic generation χ tensor microscopy for tissue imaging

delete2009-05-08
delete59
PRE
AI
W
Wei‐Liang Chen
T
Tsung-Hsian Li
P
Ping-Jung Su
C
Chen-Kuan Chou
P
Peter T. Fwu
S
Sung‐Jan Lin
D
Daekeun Kim
P
Peter T. C. So *
C
Chen‐Yuan Dong
DOI:10.1063/1.3132062delete
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摘要

摘要

En 中文
Important biological molecules such as collagen and myosin are strong second harmonic generators. The polarization dependence of second-harmonic generation (SHG) is a property of the second order susceptibility elements (chi tensor) of the molecules that produce the signal. In this work, we used polarization SHG microscopy to image and map pixel scale polarization anisotropy information of collagen-muscle junction of chicken wing and the dermis of human skin. We show that the variation in the chi tensor components can be displayed as images to show the contrast between different molecular sources of SHG.
Keyword:
biomedical optical imaging
light polarisation
optical harmonic generation
proteins
skin
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期刊

Applied Physics Letters 封面图
Applied Physics Letters
IF:
3.6
论文数:
10.4W
被引数:
17.8W

机构

N
National Taiwan University
学者数:
4.7W
论文数: 4.2W
被引数: 3.6W