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Selective reduction of the light peak-to-dark trough ratio in reticular macular disease: an electrooculography study
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DOI：10.3389/fnins.2026.1865041.png)
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Abstract
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PurposeTo compare electrooculogram (EOG) parameters between eyes with reticular macular disease (RMD) and eyes with early-to-intermediate age-related macular degeneration (AMD) without reticular pseudodrusen (RPD); and to assess whether RMD is associated with generalized RPE–photoreceptor complex dysfunction.MethodsIn this observational cross-sectional study; 42 eyes from 21 patients were analyzed (without-RPD group: 28 eyes; RMD group: 14 eyes). RMD was diagnosed using multimodal imaging (infrared reflectance and SD-OCT). EOGs were recorded with the RETI-port/scan 21 system according to ISCEV standards. Extracted parameters included dark trough (DT); light peak (LP); light rise time (Light Rise); and the LP:DT ratio. Group comparisons used the Wilcoxon rank-sum test. Linear regression evaluated the association between RMD and LP:DT ratio with and without adjustment for age.ResultsAge did not differ between groups (median 69 vs. 72 years; P = 0.5). Absolute standing potentials were similar (DT: 598 vs. 681 μV; P = 0.2; LP: 1; 092 vs. 1; 150 μV; P = 0.8). Light rise time was also similar (8.00 [IQR 7.50–9.00] vs. 8.00 [IQR 7.00–9.00] min; P = 0.6). In contrast; the LP:DT ratio was significantly reduced in RMD (1.65 [1.50–1.80]) compared with without-RPD controls (1.90 [1.80–2.10]; P = 0.0043). RMD was independently associated with a lower LP:DT ratio (β = −0.25; 95% CI [−0.41 to −0.09]; P = 0.004).ConclusionCompared with AMD eyes without RPD; RMD eyes demonstrate a selectively reduced LP:DT ratio without a change in absolute standing potentials or light rise timing. This EOG pattern supports attenuated light response consistent with generalized dysfunction of the RPE–photoreceptor complex in RMD.
Keywords:
age-related macular degeneration (AMD)
retinal pigment epithelium (RPE)
electrooculography (EOG)
reticular macular disease
reticular pseudodrusen
RPE-photoreceptor complex
subretinal drusenoid deposits
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