Selenium in Aging and Longevity

aging

selenoproteins

selenium-binding proteins

oxidative stress

Ca2+

cell-death

27-OHC

,

27-hydroxycholesterol

AD

,

Alzheimer’s Disease

CHOP

,

C/EBP homologous protein

DIO

,

thyroxine deiodinase

ER

,

endoplasmic reticulum

FAD

,

flavin adenine dinucleotide

GPX

,

glutathione peroxidase

HR

,

hazard ratio

HSPA1L

,

70 kDa heat-shock protein 1L

IGF-1

,

insulin-like growth factor-1

miR

,

microRNA

MSRB1

,

methionine sulfoxide reductase B1

NFATc2

,

nuclear factor of activated T-cells cytoplasmic-2

NF-κB

,

nuclear factor kappa B

Nrf2

,

nuclear factor erythroid 2-related factor 2

NMD

,

nonsense-mediated decay

PACAP

,

pituitary adenylate cyclase-activating polypeptide

PPARγ

,

peroxisome proliferator-activated receptor-γ

PTP

,

protein tyrosine phosphatase

RANKL

,

receptor activator of nuclear factor-κΒ ligand

ROS

,

reactive oxygen species

RyR

,

ryanodine receptor/Ca2+-release channel

SC

,

satellite cells

SECIS

,

selenocysteine insertion sequence

SELENBP

,

Se-binding protein

SELENOF

,

selenoprotein F

SELENOH

,

selenoprotein H

SELENOI

,

selenoprotein I (CDP-ethanolamine phosphophatidyltransferase-1)

SELENOK

,

selenoprotein K

SELENOM

,

selenoprotein M

SELENON

,

selenoprotein N

SELENOO

,

selenoprotein O

SELENOP

,

selenoprotein P

SELENOS

,

selenoprotein S

SELENOT

,

selenoprotein T

SELENOV

,

selenoprotein V

SELENOW

,

selenoprotein W

SeM

,

L-selenomethione

SERCA

,

SR/ER Ca2+-ATPase pump

Sik-1

,

salt-induced kinase-1

U or Sec

,

selenocysteine

SLC7A11

,

cystine/glutamate transporter

SPHS2

,

selenophosphate synthetase 2

Txnrd

,

thioredoxin reductase