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Self-administering cannabinoids
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DOI：10.1016/j.tins.2005.05.001.png)
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摘要
En 中文
Endocannabinoids, which are typically released by principal cells in response to prolonged depolarization, act as retrograde messengers to inhibit synaptic transmission. A recent study shows that in a specific subtype of cortical interneuron, endocannabinoids released under similar circumstances can also act cell-autonomously. Here, endocannabinoids endow these neurons with a memory of their own activity in the form of a long-term change in excitability.
Keyword:
DEPOLARIZATION-INDUCED SUPPRESSION
RAT FRONTAL-CORTEX
NUCLEUS-ACCUMBENS
INHIBITION
SYNAPSES
RECEPTOR
CB1
ENDOCANNABINOIDS
NEUROTRANSMITTER
NEURONS
AI总结
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