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Self-assembled DNA nanosphere-powered confined-free self-circulating amplifier for high-fidelity microRNA imaging and clinical liquid biopsy
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DOI：10.1016/j.talanta.2026.130416.png)
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Abstract
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• Confined-free DNA nanosphere amplifier (CF-SCA) enables high-fidelity miR-21 sensing. • It solves the CHA dilemma between background leakage and sluggish reaction kinetics. • The enzyme-free platform achieves a 100 pM LOD with excellent nuclease resistance. • CF-SCA resists macromolecular crowding for dynamic in situ miRNA imaging in cells. • It successfully stratifies multi-cancer clinical serum without RNA extraction.
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