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Semaglutide ameliorates traumatic sepsis-induced cardiac injury by activating the March5-ACSL4 axis to suppress ferroptosis
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DOI：10.1016/j.freeradbiomed.2026.08.002.png)
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Abstract
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• March5 is downregulated in septic hearts and protects against ferroptosis. • March5 negatively regulates ACSL4 expression in cardiomyocytes. • Semaglutide requires March5 to suppress ACSL4 and cardiac ferroptosis. • The March5-ACSL4 axis is a potential target for sepsis-induced myocardial injury.
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