Semantic design: Programming functional genes from genomic context

doi:10.1016/j.xgen.2025.101132

2026-01-09

Yulin Huang

林平 (Ping Lin) *

DOI：10.1016/j.xgen.2025.101132

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摘要

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生成式基因组模型在创造复杂的生物系统方面具有巨大潜力，但设计精确的功能序列仍然具有挑战性。Merchant等人发表在《Nature》上的研究中提出了语义设计方法，该方法利用Evo基因组语言模型仅根据基因组上下文生成新颖的功能基因。此外，SynGenome数据库包含通过语义设计生成的超过1200亿条序列，涵盖了广泛的功能。

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Cell Genomics

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671

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Southwest University

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