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Sequence-defined polymers for biomedical applications
DOI:10.1016/j.progpolymsci.2025.101993.png)
摘要
En 中文
序列定义聚合物提供了无与伦比的结构精确性,能够实现定制化的生物相互作用、增强的稳定性和优化的功能。与传统合成聚合物不同,后者通常缺乏明确的结构,这些材料允许对分子相互作用进行精确调控,以改善生物医学性能。本综述回顾了过去十年的进展,涵盖了阐明序列-功能关系的基础研究——例如与模型凝集素的相互作用——以及直接生物医学应用,包括核苷酸递送、凝集素和蛋白质抑制、抗菌和抗病毒策略、肿瘤治疗以及生物成像。对聚合物序列的控制对于提高特异性、减少脱靶效应以及在生理环境中改善稳定性至关重要。
Keyword:
ADC
Antibody-drug conjugate
AFL
Aspergillus fumigatus
AIE
Aggregation-induced emission
AMP
Antimicrobial peptide
COVID
Corona virus disease
CPT
Camptothecin
CRD
Carbohydrate recognition domain
CRISPR
Clustered regularly interspaced short palindromic repeats
G-CSF
Granulocyte colony-stimulating factor
DAR
Drug-to-antibody ratio
DC-SIGN
Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin
DNA
Deoxyribonucleic acid
DNS
Dansyl
DOPC
1,2-dioleoyl-sn-glycero-3-phosphocholine
DOX
Doxorubicin
DSPC
1,2-distearoyl-sn-glycero-3-phosphocholine
EG
Ethylene glycol
EGFR
Epidermal growth factor receptor
EPR
Enhanced permeability and retention
ESKAPE
Enterococcus faecium, S. aureus, Klebsiella pneumoniae, Acinetobacter baumannii, P. aeruginosa and Enterobacter
FA
Fatty acid
FABS
Fluorescent-activated bead sorting
FRET
Förster resonance energy transfer
GCP
Guanidiniocarbonyl-pyrrole
GSH
Glutathione
GUV
Giant unilamellar vesicle
HBV
Hepatitis B virus
HIPS
Hydrazino-iso-Pictet-Spengler
HIV
Human immunodeficiency virus
HPA
Helix pomatia agglutinin
HPV
Human Papillomavirus
HSV
Herpes Simplex Virus
IEG
Iterative exponential growth
ITC
Isothermal titration calorimetry
KRAS
Kirsten rat sarcoma viral oncogene homolog
LAF
Lipo amino fatty acid
MALDI-TOF MS
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
MHV
Murine Hepatitis Virus
MI
Maleimide
MMAE
Monomethyl auristatin E
MRI
Magnetic resonance imaging
mRNA
messenger ribonucleic acid
MTX
methotrexate
NES
Nuclear export signal
NMR
Nuclear magnetic resonance
PBAE
poly(β-amino ester)
PCI
Protein-carbohydrate interaction
pDNA
plasmid Deoxyribonucleic acid
PEG
Polyethylene glycol
PLGA
Poly(lactic-co-glycolic acid)
PNA
Peptide nucleic acid
PPI
Protein-protein interaction
PPII
Polyproline type II
PSAR
Polysarcosine
PT
pretubulysin
PTX
Paclitaxel
RAS
Rat Sarcoma
RNA
Ribonucleic acid
SARS
Severe acute respiratory syndrome
SBA
Soybean agglutinin
SDS-PAGE
Sodium dodecyl-sulfate polyacrylamide gel electrophoresis
sgRNA
single guide ribonucleic acid
siRNA
small interfering ribonucleic acid
SNR
Signal-to-noise ratio
TCPP
Meso-tetrakis(4-carboxyphenyl)porphyrin
m-THPC
Meta-tetra(hydroxyphenyl)-chlorin
TME
Tumor microenvironment
TPE
Tetraphenylethene
UV
Ultraviolet
VVL
Vicia villosa lectin
期刊
IF:
26.1
论文数:
1.4K
被引数:
3.0W
机构
暂无机构信息
引用论文
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ADVANCED MATERIALS
IF26.8

