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Sequence-defined polymers for predictable gene delivery

delete2026-07-17
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PRE
AI
C
Cameron W. Evans *
C
Cooper M. Kyrwood
L
Lennart J. Schaefer
K
Kai Chen
C
Craig A. Bell
K
Kristofer J. Thurecht
X
Xiaojuan Qi
H
Haibo Jiang
C
Cameron Alexander
S
Sébastien Perrier
V
Vincent M. Rotello
K
K. Swaminathan Iyer *
DOI：10.1038/s41570-026-00850-7delete
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摘要

摘要

En 中文
聚合物介导的基因递送正从随机设计方法向精确分子工程发展。传统聚合物虽然能有效实现核酸复合，但在结构异质性、不可预测的药代动力学和低效的内体逃逸方面面临挑战。这些挑战促使人们对序列定义的聚合物体系产生兴趣，这些体系能够实现对单体组成、电荷分布和功能性的原子级控制。序列定义的聚合物为建立稳健的结构-功能关系、克服生物屏障以及实现靶向递送至特定组织提供了机会。本文综述了聚合物基因载体的结构演变，并强调了结构精度的提高如何与功能性能的增强相关联。能够实现序列控制的合成方法被分析，从固相方法到流化学和超分子模板。通过整合聚合物科学与生物学结果，我们提出一个战略框架，以应对非病毒基因递送中持续存在的挑战。 聚合物介导的非病毒基因递送通常效率低下且结构异质。本文探讨了序列定义聚合物、先进合成、成像和计算设计如何能够实现精确、可重复和可编程的聚合物体系，以实现高效且具有临床可转化性的核酸递送。

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Nature Reviews Chemistry 封面图
Nature Reviews Chemistry
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51.7
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