Sequential addition of reprogramming factors improves efficiency

Xavier Gaeta

doi:10.1038/ncb2800

2013-07-01

DOI：10.1038/ncb2800

摘要

En 中文

Addition of a specific set of transcription factors reprograms somatic cell nuclei to a pluripotent state. Sequential addition of these factors, rather than the simultaneous exposure used in standard protocols, improves reprogramming efficiency. This sequential method favours a transition through a state with enhanced mesenchymal characteristics before driving an epithelial transformation on the way to the pluripotent state.

Keyword:

SOMATIC-CELLS

PLURIPOTENCY

期刊

Nature Cell Biology

IF:

19.1

论文数:

6.2K

被引数:

4.8W

机构

University of California System

学者数:

37.7W

论文数: 33.8W

被引数: 6.6K

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