Sequential epigenetic therapy in AML

doi:10.1182/blood.2024026916

2025-02-13

PRE

Wang, Yuanting

Christopher R. Vakoc

DOI：10.1182/blood.2024026916

原文链接

原文求助

摘要

Keyword:

BET

RESISTANCE

期刊

Blood

IF:

23.1

论文数:

5.5K

被引数:

16.6W

机构

暂无机构信息

引用论文

Pelabresib in Combination with Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Patients with Myelofibrosis: Results of the MANIFEST-2 Randomized, Double-Blind, Phase 3 Study

Blood

IF0

2023-11-02

PREAI

Raajit K. Rampal; Sebastian Grosicki; Dominik Chraniuk; Elisabetta Abruzzese; Prithviraj Bose; Aaron T. Gerds; Alessandro M. Vannucchi; Francesca Palandri; Sung-Eun Lee; Vikas Gupta; Alessandro Lucchesi; Stephen T. Oh; Andrew T. Kuykendall; Andrea Patriarca; Alberto Alvarez-Larran; Ruben Mesa; Jean-Jacques Kiladjian; Moshe Talpaz; Morgan Harris; Sarah-Katharina Kays; Anna-Maria Jegg; Qing Li; Barbara Brown; Claire N Harrison; John Mascarenhas

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Nature

IF0

2011-10-02

OAAI

Mark A. Dawson; Rab K. Prinjha; Antje Dittmann; George Giotopoulos; Marcus Bantscheff; Wai-In Chan; Samuel C. Robson; Chun-wa Chung; Carsten Hopf; Mikhail M. Savitski; Carola Huthmacher; Emma Gudgin; Dave Lugo; Soren Beinke; Trevor D. Chapman; Emma J. Roberts; Peter E. Soden; Kurt R. Auger; Olivier Mirguet; Konstanze Doehner; Ruud Delwel; Alan K. Burnett; Phillip Jeffrey; Gerard Drewes; Kevin Lee; Brian J. P. Huntly; Tony Kouzarides

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation 急性对BET抑制剂的耐药性通过p300协同激活重塑补偿性转录程序

BLOOD

IF23.1

2025-02-13

OAAI

Shah, Viral; Osaki, Hikari; Meyerhoefer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte A.; Saura-Panella, Maria; Tarkar, Aarti; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J.; Agrawal-Singh, Shuchi; Haehnel, Patricia S.; Basheer, Faisal; Lugo, Dave; Eleftheriadou, Ioanna; Barbash, Olena; Dhar, Arindam; Kuehn, Michael W. M.; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A.; Prinjha, Rab K.; Huntly, Brian J. P.; Sasca, Daniel

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

MOLECULAR CELL

IF16.6

2014-06-01

798

OAAI

Shi, Junwei; Vakoc, Christopher R.

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

Cancer Cell

IF0

2018-01-01

OAAI

Maria Kleppe; Richard Koche; Lihua Zou; Peter van Galen; Corinne E. Hill; Lauren Dong; Sofie De Groote; Efthymia Papalexi; Amritha V. Hanasoge Somasundara; Keith Cordner; Matthew Keller; Noushin Farnoud; Juan Medina; Erin McGovern; Jaime Reyes; Justin Roberts; Matthew Witkin; Franck Rapaport; Julie Teruya-Feldstein; Jun Qi; Raajit Rampal; Bradley E. Bernstein; James E. Bradner; Ross L. Levine

Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein of the testis carcinoma and other cancers: Results of a Phase I/II open-label, dose escalation study

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2021-11-26

OAAI

Cousin, Sophie; Blay, Jean-Yves; Garcia, Irene Brana; de Bono, Johann S.; Le Tourneau, Christophe; Moreno, Victor; Trigo, Jose; Hann, Christine L.; Azad, Arun A.; Im, Seock-Ah; Cassier, Philippe A.; French, Christopher A.; Italiano, Antoine; Keedy, Vicki L.; Plummer, Ruth; Sablin, Marie-Paule; Hemming, Matthew L.; Ferron-Brady, Geraldine; Wyce, Anastasia; Khaled, Ahmed; Datta, Antara; Foley, Shawn W.; McCabe, Michael T.; Wu, Yuehui; Horner, Thierry; Kremer, Brandon E.; Dhar, Arindam; O'Dwyer, Peter J.; Shapiro, Geoffrey I.; Piha-Paul, Sarina A.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Nature

IF0

2011-08-03

OAAI

Johannes Zuber; Junwei Shi; Eric Wang; Amy R. Rappaport; Harald Herrmann; Edward A. Sison; Daniel Magoon; Jun Qi; Katharina Blatt; Mark Wunderlich; Meredith J. Taylor; Christopher Johns; Agustin Chicas; James C. Mulloy; Scott C. Kogan; Patrick Brown; Peter Valent; James E. Bradner; Scott W. Lowe; Christopher R. Vakoc

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

Nature

IF0

2015-09-14

OAAI

Philipp Rathert; Mareike Roth; Tobias Neumann; Felix Muerdter; Jae-Seok Roe; Matthias Muhar; Sumit Deswal; Sabine Cerny-Reiterer; Barbara Peter; Julian Jude; Thomas Hoffmann; Łukasz M. Boryń; Elin Axelsson; Norbert Schweifer; Ulrike Tontsch-Grunt; Lukas E. Dow; Davide Gianni; Mark Pearson; Peter Valent; Alexander Stark; Norbert Kraut; Christopher R. Vakoc; Johannes Zuber

BET inhibitor resistance emerges from leukaemia stem cells

Nature

IF0

2015-09-14

OAAI

Chun Yew Fong; Omer Gilan; Enid Y. N. Lam; Alan F. Rubin; Sarah Ftouni; Dean Tyler; Kym Stanley; Devbarna Sinha; Paul Yeh; Jessica Morison; George Giotopoulos; Dave Lugo; Philip Jeffrey; Stanley Chun-Wei Lee; Christopher Carpenter; Richard Gregory; Robert G. Ramsay; Steven W. Lane; Omar Abdel-Wahab; Tony Kouzarides; Ricky W. Johnstone; Sarah-Jane Dawson; Brian J. P. Huntly; Rab K. Prinjha; Anthony T. Papenfuss; Mark A. Dawson

A Phase I/II Open-Label Study of Molibresib for the Treatment of Relapsed/Refractory Hematologic Malignancies

CLINICAL CANCER RESEARCH

IF10.2

2022-11-09

OAAI

Dawson, Mark A.; Borthakur, Gautam; Huntly, Brian J. P.; Karadimitris, Anastasios; Alegre, Adrian; Chaidos, Aristeidis; Vogl, Dan T.; Pollyea, Daniel A.; Davies, Faith E.; Morgan, Gareth J.; Glass, Jacob L.; Kamdar, Manali; Mateos, Maria -Victoria; Tovar, Natalia; Yeh, Paul; Delgado, Regina Garcia; Basheer, Faisal; Marando, Ludovica; Gallipoli, Paolo; Wyce, Anastasia; Krishnatry, Anu Shilpa; Barbash, Olena; Bakirtzi, Evi; Ferron-Brady, Geraldine; Karpinich, Natalie O.; McCabe, Michael T.; Foley, Shawn W.; Horner, Thierry; Dhar, Arindam; Kremer, Brandon E.; Dickinson, Michael

没有更多内容