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Sex-specific contribution of endothelial AT1aRs to avoidance behaviors and BBB changes in a mouse model of PTSD
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DOI：10.1016/j.nbd.2026.107547.png)
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Abstract
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• Endothelial-specific deletion of AT1aR reduced anxiety-like behavior in both males and females. • Effects of endothelial-specific deletion of AT1aR were independent of trauma conditions. • Endothelial-specific deletion of AT1aR increased claudin-5 cortical expression in stressed females. • Endothelial AT1aR signaling contributes to avoidance behaviors in a sex-dependent manner.
Keywords:
Blood pressure
Angiotensin
PTSD
Blood–brain barrier
Inflammation
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