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Shape Memory Polyurethane Material with Programmable Interface Promotes Osteogenesis in vitro

delete2025-10-15
delete0
PRE
AI
X
Xingguo Zhou
邹
邹斌 (Bin Zou) *
Q
Qinghua Chen
X
Xinfeng Wang
DOI：10.1016/j.surfin.2025.107883delete
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摘要

摘要

En 中文
具有仿生特性的微图案通过力转导影响细胞行为，该过程在促进骨修复中发挥关键作用。然而，骨再生是一个涉及多种细胞类型和机制的复杂生理过程。在骨修复的早期阶段，骨植入物上的微图案表面会过早促进成骨分化。这种过早分化不利于初始细胞数量的积累，最终延缓骨生长和整体骨积累。鉴于此，制备具有优异形状记忆特性的热刺激聚氨酯，实现了微图案界面的动态响应，能够精确切换增殖与分化阶段，以增强骨整合。此外，采用MC3T3-E1的细胞增殖和ALP活性测定评估了形状记忆聚氨酯的成骨诱导效应。结果表明，智能动态膜的可转换平面界面有效促进了细胞增殖，而响应性微结构相较于静态微图案膜显著改善了早期成骨分化。

期刊

Surfaces and Interfaces 封面图
Surfaces and Interfaces
IF:
6.3
论文数:
9.8K
被引数:
2.4W

机构

Q
Qingdao University of Technology
学者数:
8.0K
论文数: 5.2K
被引数: 7.1K
S
shandong university
学者数:
9.5W
论文数: 6.4W
被引数: 94
引用论文

引用论文

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