SHARPINing integrin inhibition

Mark D. Bass

doi:10.1038/ncb2368

2011-11-02

PRE

Mark D. Bass *

DOI：10.1038/ncb2368

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摘要

En 中文

The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin beta cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the alpha-integrin subunit and interfering with the association of the beta cytodomain with activating proteins.

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期刊

Nature Cell Biology

IF:

19.1

论文数:

6.2K

被引数:

5.8W

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