.png){kind=icon}
返回
Sheehan syndrome
.png){kind=icon}
PRE
AI
DOI：10.1038/nrdp.2016.92.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Sheehan syndrome or postpartum hypopituitarism is a condition characterized by hypopituitarism due to necrosis of the pituitary gland. The initial insult is caused by massive postpartum haemorrhage (PPH), leading to impaired blood supply to the pituitary gland, which has become enlarged during pregnancy. Small sella turcica size, vasospasms (caused by PPH) and/or thrombosis (associated with pregnancy or coagulation disorders) are predisposing factors; autoimmunity might be involved in the progressive worsening of pituitary functions. Symptoms are caused by a decrease or absence of one or more of the pituitary hormones, and vary, among others, from failure to lactate and nonspecific symptoms (such as fatigue) to severe adrenal crisis. In accordance with the location of hormone-secreting cells relative to the vasculature, the secretion of growth hormone and prolactin is most commonly affected, followed by follicle-stimulating hormone and luteinizing hormone; severe necrosis of the pituitary gland also affects the secretion of thyroid-stimulating hormone and adrenocorticotropic hormone. Symptoms usually become evident years after delivery, but can, in rare cases, develop acutely. The incidence of Sheehan syndrome depends, to a large extent, on the occurrence and management of PPH. Sheehan syndrome is an important cause of hypopituitarism in developing countries, but has become rare in developed countries. Diagnosis is based on clinical manifestations combined with a history of severe PPH; hormone levels and/or stimulation tests can confirm clinical suspicion. Hormone replacement therapy is the only available management option so far.
Keyword:
HORMONE REPLACEMENT THERAPY
CLINICAL-PRACTICE GUIDELINE
BONE-MINERAL DENSITY
CORTICOTROPIN-RELEASING-HORMONE
GH-DEFICIENT PATIENTS
QUALITY-OF-LIFE
GROWTH-HORMONE
PITUITARY-GLAND
POSTPARTUM HEMORRHAGE
LYMPHOCYTIC HYPOPHYSITIS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
N
IF:
60.6
论文数:
650
被引数:
3.8W
机构
引用论文
Estimating full configuration interaction limits from a Monte Carlo selection of the expansion space
PREAI
分享收藏
分享收藏Construction of dendritic Janus nanomotors with H2O2 and NIR light dual-propulsion via a Pickering emulsion.png)
Soft Matter
Soft MatterIF0
PREAI
分享收藏分享收藏分享收藏
查看更多内容