Siderophore conjugates

Malcolm G. P. Page

doi:10.1111/nyas.12024

2013-01-24

115

PRE

Malcolm G. P. Page *

DOI：10.1111/nyas.12024

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There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram-negative bacteria. There is also a small group of natural conjugates, the sideromycins. Among the synthetic analogues that have been investigated are conjugates of nucleosides, glycopeptides, macrolides, fluroquinolones, and, above all, beta-lactams. Despite this effort, few compounds have progressed beyond experimental studies. One compound, the siderophore monosulfactam BAL30072, is in early clinical studies.

Keyword:

iron transport

sideromycin

siderophore antibiotics

BAL30072

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