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Siglec-15 promotes M2 polarization of Kupffer cells via DAP12/IRAK-M axis to alleviate acute rejection in liver transplantation
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DOI：10.1016/j.molimm.2026.04.016.png)
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Abstract
En 中文
• Acute rejection (AR) after liver transplantation can affect the patient's quality of life. • Siglec-15 is downregulated in a rat model of acute rejection after liver transplantation. • Siglec-15 promotes the polarization of Kupffer cells (KCs) towards the M2 phenotype. • Siglec-15 promotes M2 polarization of KCs through the DAP12/IRAK-M axis. • Siglec-15 overexpression alleviates acute rejection and improves survival in liver-transplanted rats.
Keywords:
AR
acute rejection
KC
Kupffer cell
ALT
alanine aminotransferase
AST
aspartate aminotransferase
IHC
immunohistochemistry
H&E
hematoxylin and eosin
Siglec-15
sialic acid-binding immunoglobulin-like lectin-15
DAP12
DNAX-activation protein 12
IRAK-M
interleukin-1 receptor-associated kinase-M
AAV9
adeno-associated virus 9
RAI
rejection activity index
ITAM
immunoreceptor tyrosine-based activation motif
MSCs
mesenchymal stromal cells
TLR
Toll-like receptors
WB
western blot
ELISA
enzyme-linked immunosorbent assay
RTPCR
real-time reverse transcription polymerase chain reaction
Liver transplantation
Acute immune rejection
Sialic acid-binding immunoglobulin-like lectin-15
Kupffer cell
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