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Simultaneous imaging and R2*mapping using a radial multi-gradient-echo (rMGE) sequence
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DOI：10.1002/jmri.20712.png)
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Purpose: To demonstrate a rapid MR technique that combines imaging and R2* mapping based on a single radial multi-gradient-echo (rMGE) data set. The technique provides a fast method for online monitoring of the administration of (super-)paramagnetic contrast agents as well as image-guided drug delivery. Materials and Methods: Data are acquired using an rMGE sequence, resulting in interleaved undersampled radial k-spaces represent representing different echo times (TEs). These data sets are reconstructed separately, yielding a series of images with different TEs used for pixelwise R2* mapping. A fast numerical algorithm implemented on a real time implemented on a real-time reconstruction platform provides online estimation of the relaxation rate R2*. Simultaneously the images are summed for the computation of a high-resolution image. Results: Convenient high-resolution R2* maps of phantoms and the liver of a healthy volunteer were obtained. In addition to stable intrinsic baseline maps, the proposed technique particularly accurate results for the high relaxtion rates observed during the presence of (super-)para-proportional to the concentration of the agent, the technique offers a rough estimate for dynamic dosage. Conclusion: The simultaneous online display of morphological and parametric information permits convenient, quantitative surveillance of contrast-agent administration.
Keyword:
real-time imaging
R2*mapping
radial multi-gradient-echo
contrast-agent quantification
image-guided delivery
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IF:
3.5
论文数:
10.0K
被引数:
2.0W
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