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Single-cell and spatial transcriptomics across populations with perianal fistulizing Crohn’s disease shows pro-inflammatory CD4+ macrophage involvement in disease progression
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DOI：10.1016/j.jcmgh.2026.101862.png)
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Abstract
En 中文
Perianal fistulizing Crohn’s disease is a severe morbidity with rectal involvement and a higher prevalence in African Americans (AA) compared to Europeans Americans (EA). In this study, we sought to define distinguishing cellular and molecular features between inflamed rectal Crohn’s disease (CD) with and without perianal fistula across populations that give new insight into disease severity or progression.
Keywords:
AA
African American
CD
Crohn’s disease
EA
European American
IF
Inflamed
M cells
Microfold epithelial cells
NI
Non inflamed
TA
Transit-amplifying epithelial cells
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