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Single-cell mechanical characterization in constriction-based cytometry
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DOI：10.1016/j.ijmecsci.2024.108979.png)
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摘要
En 中文
Mechanical characterization of suspended cells by constriction-based microfluidic devices has currently various limitations related to the available analysis models. In this work, we propose a new methodology to analyze the experiments. This approach is based on numerical simulations to describe fluid forces and cell deformation and on an extension of the quasi-linear viscoelasticity theory developed by Fung. The cells are considered visco-hyperelastic, homogeneous, and isotropic. The approach allows for assessing the mechanical parameters of individual cells, which is not possible using previous approaches, notably increasing the power of the constriction-based microfluidic technique. A practical procedure to compute mechanical parameters is proposed and demonstrated by analyzing experiments with suspended cells. The methodology developed in this work provides a convenient tool to overcome critical limitations of the state of the art and to leverage the potential of these microfluidic devices.
Keyword:
Microfluidics
Cell Mechanics
Single-cell analysis
Mechanical properties
Mechanobiology
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9.4
论文数:
1.0W
被引数:
4.5W
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