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摘要
En 中文
The inability to make broad, minimally biased measurements of a cell's proteome stands as a major bottleneck for understanding how gene expression translates into cellular phenotype. Unlike sequencing for nucleic acids, there is no dominant method for making single-cell proteomic measurements. Instead, methods typically focus on either absolute quantification of a small number of proteins or highly multiplexed protein measurements. Advances in microfluidics and output encoding have led to major improvements in both aspects. Here, we review the most recent progress that has enabled hundreds of protein measurements and ultrahigh-sensitivity quantification. We also highlight emerging technologies such as single-cell mass spectrometry that may enable unbiased measurement of cellular proteomes.
Keyword:
MASS-SPECTROMETRY
PROTEIN-DETECTION
T-CELLS
QUANTIFICATION
TISSUE
HETEROGENEITY
MOLECULES
CHIP
VARIABILITY
CYTOMETRY
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11
论文数:
6.6K
被引数:
2.0W
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Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.png)
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收藏Single-cell protein-mRNA correlation analysis enabled by multiplexed dual-analyte co-detectionSCIENTIFIC REPORTSOAAI
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