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Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson’s disease-relevant LRRK2-G2019S mutation

delete2026-06-19
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OA
AI
N
Nasser Karmali
W
Wiebke Kessler
M
Mohammad Dehestani
W
Wenhua Sun
L
Layla Drwesh
P
Polina Volos
S
Stanislav Tsitkov
A
Ashutosh Dhingra
C
Christian Thomas
S
Salvador Rodriguez-Nieto
J
Julia Tietz
D
David Schafflick
N
Noémia Fernandes
J
Julia Fitzgerald
E
Ernest Fraenkel
T
Thomas Gasser
N
Nisha Mohd Rafiq
T
Tanja Kuhlmann
V
V. Bansal *
DOI：10.1016/j.isci.2026.116368delete
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Abstract

Abstract

En 中文
• Differentiated iPSCs carrying LRRK2 p.G2019S mutation into oligodendroglial lineages • Single-cell RNA data from human iPSCs-derived cell types with or without the mutation • OPCs and ODCs derived from iPSCs provide valuable cellular context for genetic risk
Keywords:
Molecular biology
Neuroscience
Cell biology
Bioinformatics
Omics
Parkinson's disease
LRRK2
iPSCs
oligodendrocytes
oligodendrocyte precursor cells
scRNA-seq
cilia
semaphorin-plexin
hedgehog

Journal

iScience cover
iScience
IF:
4.1
Papers:
4.6K
Citations:
4.1W

Organization

U
University of Tübingen
Scholars:
295
Papers: 122
Citations: 0
G
german center for neurodegenerative diseases
Scholars:
500
Papers: 130
Citations: 0
U
university hospital munster
Scholars:
170
Papers: 70
Citations: 0
M
massachusetts institute of technology
Scholars:
3.3K
Papers: 1.2K
Citations: 0
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