Single-Shot 3D Imaging Meta-Microscope

doi:10.1021/acs.nanolett.4c03952

Single-Shot 3D Imaging Meta-Microscope

2024-10-11

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DOI：10.1021/acs.nanolett.4c03952

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Three-dimensional (3D) imaging enables high-precision and high-resolution axial positioning, which is crucial for biological imaging, semiconductor defect monitoring, and other applications. Conventional implementations rely on bulky optical elements or scanning mechanisms, resulting in low speed and complicated setups. Here, we generate the double-helix (DH) point spread function with an all-dielectric metasurface and thus innovate the 3D imaging microscope (hence dubbed meta-microscope), both in 4f and 2f imaging systems. The 4f-meta-microscope with a numerical aperture of 0.7 achieves an axial localization accuracy below 0.12 mu m within a 15.47 mu m detection range, while the 2f-DH meta-microscope with a numerical aperture of 0.3 shows a 1.12 mu m accuracy within a 227.33 mu m range. We also demonstrate single-shot and accurate 3D biological imaging of the mouse kidney tissue and peach anther, providing a comprehensive and efficient approach for 3D bioimaging and other applications through a single-shot 3D meta-microscope.

Keywords:

Metasurface

3D imaging

Double-helix pointspread function

Biological imaging

Single-Shot 3D Imaging Meta-Microscope

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