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Small molecules mediate cellular reprogramming across two kingdoms
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DOI：10.1093/jxb/erab493.png)
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The fertilized egg is the single totipotent cell from which multicellular organisms arise through the processes of cell division and differentiation. While animals typically lose their capacity to redifferentiate cells that are already fully differentiated, plant cells are thought to remain totipotent (Su et al., 2020). Every gardener knows well that plants can regenerate a full array of plant tissues from already differentiated organs. This also seems to be true for single plant cells such as protoplasts, which, under proper in vitro culture conditions, served as the initial source for generation of transgenic plants (Skoog and Miller, 1957; Birnbaum and Sanchez Alvarado, 2008). However, the mechanisms behind the totipotency of plant cells remain elusive, with the exception of the knowledge that the developmental fate of regenerating tissues can be directed by the ratio of two plant hormones, auxin and cytokinin (Skoog and Miller, 1957).
Keyword:
Auxin
brassinosteroids
chemical reprogramming
cell reprogramming
glycogen synthase kinase
microspore embryogenesis
plant hormone interaction
small molecule inhibitors
somatic embryogenesis
期刊
IF:
5.7
论文数:
1.3W
被引数:
6.4W
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