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Small Networks Encode Decision-Making in Primary Auditory Cortex
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DOI：10.1016/j.neuron.2018.01.019.png)
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摘要
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Sensory detection tasks enhance representations of behaviorally meaningful stimuli in primary auditory cortex (A1). However, it remains unclear how A1 encodes decision-making. Neurons in A1 layer 2/3 (L2/3) show heterogeneous stimulus selectivity and complex anatomical connectivity, and receive input from prefrontal cortex. Thus, task-related modulation of activity in A1 L2/3 might differ across subpopulations. To study the neural coding of decision-making, we used two-photon imaging in A1 L2/3 of mice performing a tone-detection task. Neural responses to targets showed attentional gain and encoded behavioral choice. To characterize network representation of behavioral choice, we analyzed functional connectivity using Granger causality, pairwise noise correlations, and neural decoding. During task performance, small groups of four to five neurons became sparsely linked, locally clustered, and rostro-caudally oriented, while noise correlations both increased and decreased. Our results suggest that sensory-based decision-making involves small neural networks driven by the sum of sensory input, attentional gain, and behavioral choice.
Keyword:
LOCAL CORTICAL CIRCUITS
VISUAL-CORTEX
FUNCTIONAL-ORGANIZATION
SELECTIVE ATTENTION
GRANGER CAUSALITY
RECEPTIVE-FIELDS
PLASTICITY
CONNECTIVITY
NEURONS
DEPRIVATION
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期刊
IF:
15
论文数:
1.4W
被引数:
9.9W
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